Patient and Healthcare Provider Resource

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Tretinoin (Vesanoid®) is used to treat adult and pediatric patients with acute promyelocytic leukemia (APL).

Our Medication Sheet

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Page 1 TER TRETINOIN ORAL CHEMOTHERAPY EDUCATION Name of your medication Generic name — tretinoin TREH tih NOYN Brand name — Vesanoid® VEH suh noyd Other name — ATRA all trans retinoic acid Approved uses Tretinoin is used to treat adult and pediatric patients with acute promyelocytic leukemia APL . Dose and schedule Taking tretinoin as instructed is important to allow your treatment to be as effective as possible, so here are some key points to remember. Your dose is based on many factors, including your height and weight, overall health, and diagnosis. Tretinoin should be taken with food, at the same time twice a day. Tretinoin should be taken whole and not crushed, cut, or dissolved. If you are unable to swallow tretinoin, talk to your care provider or pharmacist for possible options. If you miss a dose of tretinoin, do not take an extra dose or two doses at one time. Simply take your next dose at the regularly scheduled time. Be sure to write down if you miss a dose and let your care provider know about any missed doses. Storage and handling Handle tretinoin with care. Just like when chemotherapy is given into the vein, this drug can be toxic, and exposure of the drug to others should be limited. Store tretinoin at room temperature 68°F–77°F in a dry location away from light. Keep tretinoin out of reach of children and pets. Leave tretinoin in the provided packaging until it is ready to be taken. Whenever possible, give tretinoin to yourself and follow the steps below. If a family member, friend, or caregiver needs to give tretinoin to you, they also need to follow these steps: 1. Wash hands with soap and water. 2. Put on gloves to avoid touching the medication. Gloves are not necessary if you give the drug to yourself. 3. Gently transfer the tretinoin from its package to a small medicine or other disposable cup. 4. Administer the medicine immediately by mouth with water. 5. Remove gloves and do not use them for anything else. 6. Throw gloves and medicine cup in household trash. 7. Wash hands with soap and water. If a daily pill box or pill reminder is used, a separate one should be used for tretinoin. Do not mix other medications into the box with tretinoin. The person filling the box or reminder should wear gloves. Gloves are not necessary if you are filling the box or reminder. When empty, the box or reminder should be washed with soap and water before refilling. Be sure to wash hands with soap and water after the task is complete, whether or not gloves are worn.

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