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Exemestane (Aromasin®) is used in the treatment of certain types of hormone-dependent breast cancer in postmenopausal women.

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Page 1 EXEMESTANE ORAL CHEMOTHERAPY EDUCATION Name of your medication Generic name — exemestane EK seh MEH stayn Brand name — Aromasin® uh ROH muh sin Approved uses Exemestane is used in the treatment of certain types of hormone dependent breast cancer in postmenopausal women Dose and schedule Taking exemestane as instructed is important to allow your treatment to be as effective as possible so here are some key points to remember o Your dose may vary but the usual dose of exemestane is 25 milligrams 25 mg to be taken by mouth at a scheduled time once a day o Exemestane should be taken with food at the same time each day o Exemestane should be taken whole and not crushed cut or dissolved If you are unable to swallow exemestane talk to your care provider or pharmacist for possible options o If you miss a dose of exemestane do not take an extra dose or two doses at one time Simply take your next dose at the regularly scheduled time Be sure to write down if you miss a dose and let your care provider know about any missed doses Storage and handling Handle exemestane with care Just like when chemotherapy is given into the vein this drug can be toxic and exposure of the drug to others should be limited o Store exemestane at room temperature 68°F–77°F in a dry location away from light o Keep exemestane out of reach of children and pets o Leave exemestane in the provided packaging until it is ready to be taken o Whenever possible give exemestane to yourself and follow the steps below If a family member friend or caregiver needs to give exemestane to you they also need to follow these steps 1 Wash hands with soap and water 2 Put on gloves to avoid touching the medication Gloves are not necessary if you give the drug to yourself 3 Gently transfer the exemestane from its package to a small medicine or other disposable cup 4 Administer the medicine immediately by mouth with water 5 Remove gloves and do not use them for anything else 6 Throw gloves and medicine cup in household trash 7 Wash hands with soap and water EXEMESTANE ORAL CHEMOTHERAPY EDUCATION Page 2 o If a daily pill box or pill reminder is used a separate one should be used for exemestane Do not mix other medications into the box with exemestane The person filling the box or reminder should wear gloves gloves are not necessary if you are filling the box or reminder When empty the box or reminder should be washed with soap and water before refilling Be sure to wash hands with soap and water after the task is complete whether or not gloves are worn o If you have any unused exemestane do not throw it in the trash and do not flush it down the sink or toilet Talk to your care provider or pharmacist about proper disposal of exemestane o If you are traveling put your exemestane in a sealed plastic bag Ask your pharmacist if any additional travel precautions are needed Handling body fluids and waste Because exemestane remains in your body for several days after it is taken some of the drug may be present in urine stool sweat or vomit Once you have started to take exemestane it is important to follow the instructions below every day for as long as your treatment lasts This is to keep yourself loved ones and the environment as safe as possible o Pregnant women should avoid touching anything that may be soiled with body fluids from the patient o Toilet and septic systems You may use the same toilet septic tank and/or sewer that you usually use If you have a low flow toilet close the lid and flush twice to ensure all waste has been discarded If the toilet or toilet seat becomes soiled with urine stool or vomit clean the surfaces before other people use the toilet Wash hands with soap and water after using the toilet o If you need a bedpan be sure your caregiver knows to wear gloves to assist with cleanup and to wash the bedpan with soap and water every day o If you do not have good control of bladder or bowels use a disposable pad with a plastic back a diaper or a sheet to absorb body waste o Wash any skin that has been exposed to body waste or exemestane with soap and water o Linens or clothing that are soiled with body fluids or body waste should be washed separately from other linens and clothing If you do not have a washer place the soiled linens in a plastic bag until they can be washed o Wash hands with soap and water after touching linens or clothing that may be soiled with body fluids Drug and food interactions o Exemestane has many drug interactions Inform your care providers of all prescription medications over the counter medications vitamins and herbal products o Exemestane should be taken with food o Talk with your care provider or pharmacist before taking new medications or supplements or receiving any vaccines EXEMESTANE ORAL CHEMOTHERAPY EDUCATION Page 3 Side Effects of Exemestane The common side effects that have been known to happen in more than 30% of patients taking exemestane are listed in the left side of this table You MAY NOT experience these side effects Options to help manage any side effects that do occur are included on the right side of this table These should be discussed with your care provider If you experience any side effect you cannot manage or that is not listed here contact your care provider Possible Side Effect Management Hot flashes sudden sweating and feelings of warmth If hot flashes are bothersome Mild regular exercise program may help Consult first with your care provider Try staying in a cool environment Wear layers so that you can remove outer layers when experiencing a hot flash Avoid or limit caffeine spicy food alcohol and stress which may worsen hot flashes Inform your care provider if your hot flashes are bothersome as there may be medications that can help If you experience ANY uncontrolled side effect call your physician or healthcare center immediately INSTITUTIONAL CONTACT INFO Pregnancy sexual activity and contraception o Women should not become pregnant and men should not get a partner pregnant while taking exemestane Men and women of childbearing age and potential should use effective contraception during therapy and for a minimum of one month after the last dose of exemestane o Do not breastfeed while taking exemestane and for one month after the last dose of exemestane o Inform your care provider if you become pregnant o It is safe to hug and kiss Special precautions may be needed for sexual activity while on oral chemotherapy and you are encouraged to ask your care provider Obtaining medication o Talk with your care provider about the process for obtaining your exemestane PHARMACY OR SPECIALTY PHARMACY CONTACT INFO EXEMESTANE ORAL CHEMOTHERAPY EDUCATION Page 4 Additional resources Product website www pfizer com/products/product detail/aromasin Product prescribing information http //labeling pfizer com/ShowLabeling aspx?id=523 Product resources www aromasin com/tools and resources Updated – September 3 2017 Additional instructions Important notice The Association of Community Cancer Centers ACCC Hematology/Oncology Pharmacy Association HOPA National Community Oncology Dispensing Association Inc NCODA and Oncology Nursing Society ONS have collaborated in gathering information for and developing this patient education guide This guide represents a brief summary of the medication derived from information provided by the drug manufacturer and other resources This guide does not cover all existing information related to the possible uses directions doses precautions warnings interactions adverse effects or risks associated with this medication and should not substitute for the advice of a qualified healthcare professional Provision of this guide is for informational purposes only and does not constitute or imply endorsement recommendation or favoring of this medication by ACCC HOPA NCODA or ONS who assume no liability for and cannot ensure the accuracy of the information presented The collaborators are not making any representations with respect to the medications whatsoever and any and all decisions with respect to such medications are at the sole risk of the individual consuming the medication All decisions related to taking this medication should be made with the guidance and under the direction of a qualified healthcare professional Permission Oral Chemotherapy Education OCE sheets are provided as a free educational resource for patients with cancer in need of concise easy to understand information about oral cancer drugs Healthcare providers are permitted to copy and distribute the sheets to patients as well as direct patients to the OCE website for information However commercial reproduction or reuse as well as rebranding or reposting of any type are strictly prohibited without permission of the copyright holder Please email permission requests and licensing inquiries to Contact@NCODA org Copyright © 2017 by Hematology/Oncology Pharmacy Association All rights reserved

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