Asciminib (Scemblix®) is used to treat chronic myeloid leukemia (CML).
Our Medication Sheet
This sheet is available to download as an Adobe PDF.
Page 1 Name of your medication Generic name — asciminib (as-KIM-uh-nib) Brand name — SCEMBLIX® Approved uses Asciminib is used to treat chronic myeloid leukemia (CML). Dose and schedule Taking asciminib as instructed is important to allow your treatment to be as effective as possible, so here are some key points to remember. o Your dose may vary, but the usual dose of asciminib is: • 80 milligrams (80 mg) to be taken by mouth at a scheduled time once a day OR • 40 milligrams (40 mg) to be taken by mouth at a scheduled time twice a day approximately 12 hours apart • 200 milligrams (200 mg) to be taken by mouth at a scheduled time twice a day approximately 12 hours apart o Asciminib should be taken without food, at the same time each day. Do not eat for at least 2 hours before and 1 hour after taking asciminib. o Asciminib should be taken whole and not crushed, cut, or dissolved. If you are unable to swallow asciminib, talk to your care provider or pharmacist for possible options. o If you miss a dose of asciminib: • For once daily dosing: only take the missed dose if it has been less than 12 hours since you were supposed to take it. Then take the next dose at the regularly scheduled time. • For twice daily dosing: only take the missed dose if it has been less than 6 hours since you were supposed to take it. • Do not take two doses at one time. • Be sure to write down if you miss a dose and let your care provider know about any missed doses. ASCIMINIB ORAL CHEMOTHERAPY EDUCATION Page 2 Drug and food interactions o Asciminib has many drug interactions; please inform your care providers of all prescription medications, over-the-counter medications, vitamins, and herbal products. o Grapefruit or grapefruit juice may interact with asciminib; avoid eating or drinking these during treatment with asciminib. o Talk with your care provider or pharmacist before taking new medications or supplements, or receiving any vaccines. Storage and handling Handle asciminib with care. Just like when chemotherapy is given into the vein, this drug can be toxic, and exposure of the drug to others should be limited. o Store asciminib at room temperature (68 to 77 F) in a dry location away from light. o Keep asciminib out of reach of children and pets. o Leave asciminib in the provided packaging until it is ready to be taken. o Whenever possible, you should give asciminib to yourself and follow the steps below. If a family member, friend, or caregiver needs to give the asciminib to you, they also need to follow these steps. 1. Wash hands with soap and water. 2. Put on gloves to avoid touching the medication. (Gloves are not necessary if you give the drug to yourself.) 3. Gently transfer the asciminib from its package to a small medicine or other disposable cup. 4. Administer the medicine immediately by mouth with water. 5. Remove gloves and do not use them for anything else. 6. Throw gloves and medicine cup in household trash. 7. Wash hands with soap and water. o A daily pill box or pill reminder is NOT recommended to be used with asciminib. o If you have any unused asciminib, do not throw it in the trash and do not flush it down the sink or toilet. Talk to your care provider or pharmacist about proper disposal of asciminib. o If you are traveling, put your asciminib in a separate sealed plastic bag. Ask your pharmacist if any additional travel precautions are needed.